Level of hormones depending on age
Age and endocrinology
Hormones undergo significant changes depending on age. The level of most hormones is reduced. The level of some hormones remains normal, including TSH, ACTH (basal), thyroxine, cortisol (basal), 1,25-dihydroxycholecalciferol, insulin (in some cases, increases) and estradiol (in men). ACTH levels (in response to stimulation with cortico-liberin-releasing hormone), follicle-lostimulating hormone, sex hormone-binding globulin and an inhibitor (in men) are increasing; gonadotropins (in women), adrenaline (in old people), para-thyroid hormone, norepinephrine, cholecystokinin, vasoactive interstitial peptide, arginine, vazopresin, (with loss of circadian rhythm), atrial natriuretic hormone, associating with an atrial syringe, vasopressin; defects; these disorders lead to decreased function. Many age-related changes are similar to thosewhich develop in patients with hormonal deficiency, confirming the hypothesis “a hormonal source of youth” (speculative opinions are associated with this, that some changes associated with age can be eliminated by taking one or more deficient hormones). Some evidence suggests that the use of certain hormones by adults can improve functional status (for example, muscle strength, bone mineral density), but there is little data regarding their effect on mortality. In some cases, hormone intake is harmful, as, for example, the appointment of estrogen to most older women.
Various theories claim that age-related decline in hormone levels is a protective slowdown in cell metabolism. This concept of the theory of age is based on the principle of "intensity of life" (for example, the metabolic processes in the body are more intense, death occurs faster). This concept seems to be based on studies of the effectiveness of dietary restrictions. Constraints that reduce the levels of hormones that stimulate metabolism, thus, slow down metabolic processes; it prolonged life in rodents.
The levels of dehydroepiandrosterone (DHEA) and its sulfate decrease dramatically with age.Contrary to the optimism of the significant effect of DHEA on the aging of people, most control studies failed to prove this.
Pregnenolone is the precursor of all known steroid hormones.
Like DHEA, its levels decline with age. Studies in 1940 demonstrated its reliability and beneficial effect in individuals with arthritis, but additional studies failed to prove any significant effect on memory and muscle strength.
Levels of GH and its peripheral endocrine mediator (IGF-1) decrease with age. Although the appointment of GH to adults sometimes increases muscle mass, but does not increase muscle strength (this was tried to use in exhausted people). Opposite effects (for example, carpal tunnel syndrome, arthralgia, water retention), unfortunately, are similar. STH has a positive effect in the short-term treatment of some patients with wasting, but in critical cases of wasting, an increase in the level of growth hormone can lead to death. Funds that stimulate the production of growth hormone, according to most physiological characteristics, improve the overall condition and reduce the risk.
Melatonin levels, the pineal hormone, also decrease with age. This decrease may play an important role in the disturbance of circadian rhythms with age. The use of estrogen and testosterone in elderly patients.
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